Like the film 'Waking Life', the show deals with existential topics regarding death, religion, drug abuse, and much more. The characters anxieties and regrets are mentioned frequently.
The Midnight Gospel, albeit a science fantasy dark dramedy, has a consistent theme throughout all of its episodes; all episodes deal with heavy topics such as drugs, pregnancy and the afterlife, sorcery and other forms of ritualistic magic, emotional connection, self-awareness, meditation and self-acceptance, institutionalization of death, the concept of birth, life, death altogether and accepting death as it is.