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When a woman (Desirée Matthews) experiences a miscarriage, she arrives at her grandmother's (Academy Award winner Olympia Dukakis) door seeking a witness to her profound grief. As the two women struggle to find their way through this devastating loss, the ancient power of sisterhood is revealed in the sacred bond they share. Inspired by untold stories often endured alone in silence, 'The Great Unknown' offers a deep questioning of, and eventual surrender to, the vast mysteries of life.