Superman: The Mad Scientist (1941)

The Mad Scientist threatens to use his Electrothanasia-Ray to cause "total destruction" to the fools who had laughed at him. Lois Lane pilots an airplane to his mountaintop laboratory, but The Scientist has her bound and gagged before she knows it. He forces her to watch on a television screen as his ray destroys a famous bridge. Next, he uses the ray to topple over the Daily Planet, but Clark Kent changes to Superman in time to save the building and put his indestructible body in front of the ray. The Mad Scientist is thrilled at the opportunity to pit his deadly machine against the Man of Steel.