There are references to Bill taking magic mushrooms with his friends. There are some descriptions of what they saw in their hallucinations, some of which are re-enacted using animation.
There are references to Bill trying cocaine.
There are references to Bill smoking, including pictures, animations, stock footage and stand-up material featuring him smoking.
Some of Bill's stand-up routines include topics such as smoking and legalizing marijuana.
There is talk about how alcohol almost destroyed Bill's career and his journey in quitting drinking.