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Lindsay and Jenny, tourists from New York visiting Germany, get a flat tire on their way to a nightclub and seek help at the house of misanthropic, psychopathic surgeon Dr. Josef Heiter. He drugs the women with Rohypnol and kidnaps them to create a human centipede by surgically connecting three people together, mouth to anus, to form a single digestive tract. What makes this creeper is the performance of the antagonist, and how realistic this portrayal can be.