A character named Jared Shapiro is 30 year old writer (Jake Goldman) dating a kindergartener.
A man rips his shirt in "Man Up"; the scene it's about a second.
In "Bye Bye, Bellum", the mayor is seen in underwear, the Miss Bellum's sensual voice is heard, and she's partially seen in bikini in the latest seven seconds of the episode.
The episode "Tiara Trouble" contains some very mild suggestive references (like representations of woman, dressing, the spontaneous songs and tiger's appearances).
The episode "Horn, Sweet Horn" have some transgender issues.
A man becomes a centaur in "Blue Ribbon Blues" and he's seen naked but nothing worse than his pectorals is seen.
In "Once Upon a Townsville", Buttercup touches Princess Bluebelle's breasts with a stick, and after they kiss on the mouth accidentally.
In "Man Up 2: Still Man-ing", several people is seen in swimming suits, and a couple is about to kissing. Also the Mayor is seen nude twice with no genitals visible that the Powerpuff Girls see disgusted (except for the first time for Bubbles).
In the short "Bubbles' Beauty Blog but on Video", the Professor is obligated to wear makeup at the end. Also in "Air Buttercup" a kid is seen in underwear briefly.