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"Y: The Last Man" is set in a post-apocalyptic world where a mysterious cataclysmic event has simultaneously killed every mammal with a Y chromosome. Surprisingly, aspiring escape artist Yorick Brown and his pet monkey Ampersand are the only two males left. The series follows Yorick as he traverses the new world, while its survivors struggle with their losses and attempt to restore world society, led by Yorick's mother Jennifer.