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When the young mouse, Max's (Neil Patrick Harris') family is killed by exterminators, he is forced to move to his Aunt's home under the White House in Washington, D.C.. There, he finds life more lively than he ever thought possible with his friends, the crusading Berkeley (Jennifer Darling), the roguish Jammet (Charlie Adler), the frazzled and periodically exploding Muggle the Lab Rat (Bobcat Goldthwait), and Moze (Dorian Harewood), the hip cockroach as they go about their lives in the U.S. President's residence.