Shameless (2004)

Lots of explicit sex scenes, both heterosexual and homosexual but no penetration shown.

No gore. Violence is modest within the cinematic/TV range.

Swearing is very frequent and used by characters from young teens to older folks of both genders.

Substance abuse and references of almost all kinds, some drugs not specifically named, is common to every episode and begins, in this social comedy, with the opening montage spoken by a parent, End Poverty, Free Drugs Now.

Explicit drug use.

Lots of drinking and smoking of cigarettes/cannabis joints in every episode.

A family who are main characters (the maguires) are involved in crime business, including drug dealing.

Ecstasy is constantly used and sold behind the bar in the pub.

In season 3 (i think) and season 6, heroin addiction is a main theme. The injecting of it is shown and is quite graphic.

Cocaine is used occasionaly.

There are intense scenes throughout all the seasons.