Edgar & Ellen (2007)

Based on a book series by Charles Ogden, lively animated series EDGAR & ELLEN revolves around the titular 12-year-old twins, whose primary mission in life is playing mischievous practical jokes (on each other as well as classmates and teachers) and putting the snooty residents of Nod's Limbs in their place. (Edgar and Ellen's adventures air as both an episodic cartoon series and longer specials.) Edgar and Ellen are voiced by Kathleen Barr and Jillian Michaels, respectively.