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Kaleb, an exotic animal lover, buys a rare spider smuggled from the Middle East. He brings it home, only to lose it after a party. The next day, an unsuspecting person in the apartment complex dies from spider bites, causing a building lockdown. As the infestation worsens, Kaleb and his friends battle the rapidly reproducing spiders, facing xenophobia, panic, and a relentless swarm of deadly arachnids.