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This series follows a former medical scientist who used to battle depression himself go on a journey to find a healthy way of living. Various methods and viewpoints are explored to help alleviate depression and its symptoms. Top scientists from all fields are interviewed, and the underlying science is explained in clear animations. In addition, celebrities from different backgrounds reveal their own experience with setbacks, mental illness, and success. Together this creates a unique mixture of role models who struggled themselves and scientists illustrating potential ways to get out of depression using different practices, which are all put to the test by the documentary filmmaker.