A man wakes up to find his penis covered in large, crusty, discolored herpes sores. This is shown close up, and the penis is visible during the first few strokes of masturbation. A little later we see it as he rubs it a couple of times.
A man and woman are shown fully nude taking turns licking each other's anus. This is shown from the side, so we don't see anal contact, just head movement, and no gore is visible. Breasts are seen, but no genitals. Afterward they lie down face up, his genitals and her breasts fully visible, her genitals mostly hidden. This scene lasts nearly a minute.
There are a couple of brief sex scenes with a man behind a woman thrusting loudly and vigorously, without nudity. One of these occurs in public to mixed reactions. Other scenes show kissing with tongues very close up.
The plot of this movie centers on anuses, on heterosexual anal intercourse and oral-anal fetishes, on sexually transmitted diseases, and on drug use. Activity, description, and conversation related to these matters recur throughout the film, usually in explicit and vulgar terms.
A feces-covered woman seen from the front may appear nude but is wearing flesh-colored clothing over breasts and genitals, so no private parts are seen.
A pop art painting showing a nude woman from the front is visible several times. The view zooms in on a photo showing the breast and nipple of a woman feeding an infant. Another photo shows an unclothed infant from the rear. Four people are seen sitting on side-by-side toilets, pants down around their legs, but no genitals visible.
A man harasses his friend by putting his unclothed genitals (not seen) near the other's face.
Condom use is discussed in a disparaging way.
Herpes is shown to limit various characters' romantic options.
The modern (2017) younger persons' dating paradigm that requires being drunk to hook up is discussed.
The Lewinsky/Clinton incident is mentioned, but not described.
One psychiatrist relates that a patient suggested showing the doctor his penis. Another one says that a knife is a phallic symbol.
Actress Betsey Brown Is director Peter Vack's real life sister. He convinced her to perform fully nude (for the first time in her career) and in graphic sex scenes, including pretending to lick a man's butthole while he licks hers. Their parents also appear in the film and watched those scenes at the premiere with a large audience.