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"Dexter's Laboratory" follows the adventures of Dexter, a boy-genius who keeps a secret laboratory hidden in his bedroom. Despite his intelligence, Dexter often faces challenges due to his hyperactive sister Dee Dee's antics in his lab. Meanwhile, Dexter contends with his rival Mandark, another genius whose evil schemes aim to outdo him. As Dexter navigates family life and battles Mandark, he must protect his inventions while maintaining the secrecy of his lab from his oblivious parents.