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FBI man Stafford is extraditing convicted killer Brett Murphy from Spain to the USA. At the last minute, Murphy's fiancée, entertainer Jean Gurney, finds that he's been taken and sneaks onto the plane. Unknown to them, a suicidal passenger has a fire-and-gas bomb in his luggage. As time ticks away, minor dramas are played out on board. When the pilots succumb to the fumes, the only available substitute is Murphy.