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Socialite Thomas Wentworth Duncan reunites with his former lover, Sally Reeves, after a trustee absconds with his fortune. Realizing he cannot afford to support Sally in the manner to which she is accustomed, Duncan impulsively accepts an offer of $250,000, then discovers that he has sold his heart to Dr. Spleen, a surgeon who plans to exchange the organ with that of Sally's uncle, Judah P. Corpus, believing it will restore the old man's youth. Duncan learns that the surgery has only been attempted twice before with a pair of dogs, neither of which survived. He tries to renege on the deal, but a huge attendant prevents him from leaving the doctor's island sanitarium. Spleen dies from excitement before he can begin the operation, leaving Duncan unscathed with his newfound wealth. Duncan and Sally marry, while Uncle Judah believes the operation to have been a success.