Men take dangerous drugs and impacts are explained at the end how people get trauma and permanent brain damage. Some are even dead. See Violence & Gore
A man is hallucinating from his drug use and imagines bugs crawling all over him and his place. He ends up showering (nothing explicit seen beyond his bare chest and back).
A woman invites a man to go back to her place, drop some "death" (Substance D), and get some tequila. We then see both of them looking and acting high after unseen drug use.
A man's boss offers him a cigarette, but he declines, saying he's getting off that (the boss smokes).
There's talk of a drug called Substance D that many people are using and/or dealing, as well as a terrorist group that's manufacturing it.
A man and another man talk about the cost of coke and he then goes through some process of separating the oil from the coke using some sort of aerosol and then putting that bag in a freezer.
A man gives some of the drugs, in pill form, to another man.
A man picks up an unlit "roach" (marijuana joint) from an ashtray (leftover from someone else).
A man rolls a joint and then gives it to another who smokes it while also having a beer.
A man hears a radio personality talking about committing suicide via downers and wine and prepares that for himself, but then goes to the liquor store to buy a more expensive bottle of wine (since his was cheap). He then takes the pills and has the wine, but then hallucinates (seeing a human type figure with many eyes all over its head).
A fast forwarded tape from a surveillance shows people in a store buying coke.
Substance D users are traced and scanned, suspicious to police activity.
A conversation is heard on a surveillance tape that the man wants to buy 10.
A field of flowers that creates an illegal drug (Substance D) is shown in a field.
A man gives a woman pills of Substance D and the man take the Substance D. They both sallow the pills and kiss.
A man watches a man smoke a joint and begins to have a blurry vision and hallucinations. He struggles covering his hand on his eyes and seeing images of his kids.
The film is about drug addiction, so there are frequent strong references .
Repeated scenes of people taking multiple pills, and drinking alcohol.
Joints are rolled and smoked by dealers.