Marmaduke (2010)

Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame (appearing in six hundred newspapers in over twenty countries) to big screen stardom in this family comedy event. A suburban family moves to a new neighborhood in Orange County, California with their large, yet lovable Great Dane, who has a tendency to wreak havoc in his own oblivious way. But it's not all living large for the Duke, who finds that fitting in with his new four-legged friends, and a potential romantic interest, isn't always easy for a super-sized teenage dog. Owen Wilson gives the beloved Great Dane his voice in the film, which also features the voices of Fergie, George Lopez, Emma Stone, and Kiefer Sutherland.