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On the mean streets of New York, four controversial and seemingly isolated stories interlock as the characters battle their own personal demons, as well as the burdens that society places on them. The story begins with an extremist pastor who tries to guide his formerly atheist wife and her wayward children into living according to his fanatical beliefs--an attempt that results in explosive consequences. The familial angst continues as a Latino family deals with the possible deportation of its father figure and also suffers the backlash of his three-year military deployment. Then, plunge into the heightened emotional discord of an isolated young man who attempts to cope with the death of his mother, an abusive relationship, and an uncontrollable disability that he tries to keep hidden. Finally, a woman's personal tragedies lead her to choose between life or death. Combined, these complex stories speak on the inescapable circumstances that people from all walks of life encounter. What some of the characters don't realize is that the only way to overcome their troubles is to face them head-on, and ultimately, the outcomes of their situations come down to one individual choice: either to stay or "RUN."