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The film begins as the world gathers to take a miracle pill scientists say prevents and cures HIV/AIDS. Hours later after the synchronized celebration ends there's a sudden and unsettling quiet that covers the globe. Then, everything turns dire as it becomes all to clear that everyone who took the pill suffers from horrific side-effects. As a few, defiant, non pill-popping survivors emerge in the small Texas town of Eliasville, they find themselves seeking refuge in an abandoned building near the town's center. Soon after Beth Anne and Phil, have finished barricading themselves safely inside they quickly realize they are not the sole survivors after encountering Samuel, pastor of the local "Gay is not Ok" Pentecostal church, along with his wife, Janice, and closeted son, Ethan. While butting their proverbial heads at every turn things get even crazier upon discovering a madcap group of vigilante survivors all of whom are challenged to band together in hopes of surviving the zombie apocalypse that surrounds them.