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"Brian" is a family drama about Danny Mancini, a vulgar, unscrupulous, ruthless restaurant owner who reluctantly takes in his Autistic teenage nephew, Brian after Brian's mother dies from a drug overdose. Danny, normally one step ahead of everybody and everything, finds that's all about to change with Brian. While taking daily criticism from his ex-wife, Elizabeth who can't help still loving Danny despite her spewing hatred of him, Danny is also dealing with his son, Charlie, who intends to follow in his father's footsteps...much to Danny's dismay. It isn't long before Charlie grows jealous of Brian and Danny's growing relationship. Complications ensue when Danny learns that due to Brian's parents' drug use during the pregnancy, Brian not only developed Autism, but his heart is smaller than normal and is prone to occasional seizures. Despite his health issues, Brian manages to remind Danny what used to be more important to him in life, bringing a warmth to Danny's estranged family, bringing them closer together. "Brian" is a story about how an underestimated, sweet Autistic boy is able to open a close minded man's eyes and reuniting an estranged family, helping them learn to depend on each other as they had before, growing to be a family once again.