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The story begins at a cemetery where Pavan is found mourning following his wife's sudden demise. He is visited by his friend Udara who comes to pay his respect, which triggers Pavan to bring memories of 7 years before, when they were close friends at the village. Apeksha is Pavan's fiancée, who finds a job many years after her graduation. Unfortunately during her medical examination, which is required at her new job, was diagnosed with an early breast cancer. The social stigma of a cancer enfolded on Apeksha and disapproval from Pavan's mother regarding their marriage makes Pavan to stroll with an unresolved mind. Apeksha struggles to get her job, life, feminine character back, with only support given to her by their good friend Udara. Udara (who is also a friend of Pavan's) struggles to get Pavan back to Apeksha. Pavan struggles to get away from Apeksha. At the climax of 'KANDULAKA APEKSHA', the destiny of the three friends is decided with Apeksha defeating her disease and all barriers.