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Saira was born into a Urdu-speaking family in India. Her mom's name is Naseem Banu. She spent much of her childhood in London and was able to debut in 1961 in a Bollywood movie 'Junglee' opposite Shammi Kapoor. At the age of 22, she got married to Yusuf Khan, alias Bollywood superstar Dilip Kumar. Saira has a niece, Shaheen, who was once married to Bollywood actor, Sumit Saigal, and the couple have a daughter, Sayesha.