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Karger was married to Ann Conley of the "Ann & Effie Conley Sisters" Vaudeville Act. He was one of the original founders and the general manager of Metro Pictures in New York before they moved to Hollywood and merged with Samuel Goldwyn and Louis B. Mayer to form MGM Pictures. His son Fred Karger was a composer and a vocal coach at Columbia Pictures. Romantically involved with a young Marilyn Monroe from 1948-1949, Fred broke with Monroe, and eventually married Jane Wyman in 1952.